Summary:
This Funding Opportunity Announcement (FOA) encourages investigators to form collaborations with an established academic, nonprofit, or commercial high throughput screening (HTS) facility that has the requisite expertise and experience to implement HTS-ready assays for the discovery and development of small molecule chemical probes.

Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatments relevant to the missions of the participating NIH Institutes, and 2) discovery and/or validation of novel, biological targets that will inform studies of disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease targets and processes.

Although this funding opportunity uses the R01 mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-14-283, which utilizes the exploratory/developmental (R21) grant mechanism.

For more information, please visit:
http://grants.nih.gov/grants/guide/pa-files/PAR-14-284.html