This Funding Opportunity Announcement (FOA) seeks applications for research projects as part of NHIR. These research projects will investigate interactions between ENMs and biological systems to generate comprehensive biological response profiles for ENMs that will be provided by Engineered nanomaterials Resource and Coordination Core (ERCC) being solicited through a companion FOA (RFA-ES-15-012). This consortium will generate biological response profiles for a select set of ENMs representing the landscape of nanotechnology applications. The research projects to be funded through this FOA will contribute to long range goals of the NIEHS Nano EHS program, i.e., to derive detailed molecular, biochemical and pathophysiological characterization of ENMs-biological interactions as influenced by physicochemical properties of ENMs. The investigators of the U01 projects as part of the NHIR consortium will carry out investigations on a common set of ENMs, and participate in annual meetings of the consortium coordinated by ERCC.
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