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The Early Detection Research Network: Biomarker Reference Laboratories (U24)


Tuesday, January 20, 2015


The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Biomarker Reference Laboratories (BRLs), one of the four scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. The proposed BRLs will conduct biomarker assay development and refinement for validation studies, and will serve as a Network resource for laboratory and clinical validation of biomarkers. The other three scientific units of the continuing EDRN program are: the Biomarker Developmental Laboratories (BDLs), which will be responsible for the development and characterization of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of early cancer; the Clinical Validation Centers (CVCs), which will conduct clinical research on the validation of biomarkers and will serve as resource centers for the EDRN by participating in collaborative biomarker validation studies with EDRN BDLs and BRLs; and the Data Management and Coordinating Center (DMCC), which will support statistical and computational analyses, informatics infrastructure, study design, coordination and support of EDRN-sponsored biomarker validation studies, and the coordination of Network-wide meetings and conferences

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