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Reagent and Reaction Development in the Service of Complex Target Synthesis: Chiral Proton Catalysis, Umpolung Amide Synthesis, and Case Studies in Therapeutic Development

Categories: Chemistry and Chemical Biology (CCB)
Speaker: Jeffrey Johnston, Vanderbilt University
Date & Time: January 8, 2013 - 11:00am
Location: Wright Rieman Auditorium
 
Our discovery that chiral nonracemic Bis(AMidine) - ‘BAM' - ligands can be effective modifiers of achiral Brønsted acids such as triflic acid became the basis for a general approach to fully stereocontrolled aza-Henry reactions. These reagents are bifunctional catalysts that rely on the basic principles of Brønsted acid (hydrogen bond) and base activation much like biological catalysts. Our latest findings in bifunctional Brønsted acid/Brønsted base catalyst design and development, reaction exploration, and target acquisition using these tools will be described. Our work to leverage chiral proton catalysis against the goal of fully enantioselective and efficient peptide synthesis via Umpolung Amide Synthesis (UmAS) will be introduced.

Advancing Nanotechnology - IAMDN New Microscopes

 

Rutgers new scanning transmission electron microscope and new helium ion microscope help researchers develop nanotechnology used to fight cancer, generate power, and create more powerful electronics. Watch the video to learn more.

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