|Electrochemically Programmed Release of Biomolecules and Nanoparticles |
Laboratory for Surface Modification
|Peter C. Searson, Johns Hopkins Univ., Institute for NanoBio Technology|
12:00 Noon, Chem. 260
The controlled release of molecules or nanoparticle conjugates is an important tool for a wide range of applications in science and engineering. Here we demonstrate electrochemically programmed release of biomolecules and nanoparticles on patterned electrodes. This technique exploits the reductive desorption of self-assembled monolayers and allows both spatially-controlled release and regeneration of small molecules (e.g. drugs), biopolymers (e.g. peptides, proteins, DNA), protein assemblies (e.g. viruses), and nanoparticles (e.g. particle-DNA conjugates). We show how programmed release is being used to gain new insight into cell de-adhesion.
Host: Adrian Mann