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Chhowalla Group Research
Gold Nanoparticles (acquired by UltraSTEM)
hybrid perovskite single crystals
rubrene OFETs
Professor Shahab Shojaei-Zadeh publishes in Phys Rev Fluids
Fabris Group Research

Aggregation, Dynamics and Interactions of Amyloid-b peptide

Speaker: Chunyu Wang, Rensselaer Polytechnic Institute
Date & Time: February 12, 2008 - 11:00am
Location: WL-Aud

Aggregation, Dynamics and Interactions of Amyloid-b peptide
Chemistry and Chemical Biology

Chunyu Wang, Rensselaer Polytechnic Institute.
11:00 AM, WL-Aud

Alzheimer's disease (AD) is the most common type of senile dementia. Brains inflicted with Alzheimer�s disease are characterized by extracellular senile plaques whose major components are the amyloid B peptides (AB). AB is widely believed to play a central role in the pathogenesis of Alzheimer�s. AB40 and AB42 are the predominant AB species in the human body. We show that while AB42 aggregates are toxic to neurons, AB40 may have a protective role in Alzheimer's. The differences in backbone and sidechain dynamics among AB40, AB42 and M35 oxidated AB42 suggest that the dynamics of AB monomers contribute to the mechanism of AB aggregation. In addition, the interactions between AB and a variety of cellular targets are probed to understand how AB leads to memory loss and ultimately dementia.

Advancing Nanotechnology - IAMDN New Microscopes


Rutgers new scanning transmission electron microscope and new helium ion microscope help researchers develop nanotechnology used to fight cancer, generate power, and create more powerful electronics. Watch the video to learn more.

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