Speaker: Chunyu Wang, Rensselaer Polytechnic Institute
Date & Time: February 12, 2008 - 11:00am
Aggregation, Dynamics and Interactions of Amyloid-b peptide
Chemistry and Chemical Biology
Chunyu Wang, Rensselaer Polytechnic Institute.
11:00 AM, WL-Aud
Alzheimer's disease (AD) is the most common type of senile dementia. Brains inflicted with Alzheimer�s disease are characterized by extracellular senile plaques whose major components are the amyloid B peptides (AB). AB is widely believed to play a central role in the pathogenesis of Alzheimer�s. AB40 and AB42 are the predominant AB species in the human body. We show that while AB42 aggregates are toxic to neurons, AB40 may have a protective role in Alzheimer's. The differences in backbone and sidechain dynamics among AB40, AB42 and M35 oxidated AB42 suggest that the dynamics of AB monomers contribute to the mechanism of AB aggregation. In addition, the interactions between AB and a variety of cellular targets are probed to understand how AB leads to memory loss and ultimately dementia.