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Peer Reviewed Cancer Research Program -- Translational Team Science Award


Tuesday, June 16, 2015

The FY15 PRCRP Translational Team Science Award (TTSA) is new for FY15 and supports translational correlative studies associated with an existing or completed clinical trial that could lead to a future clinical application or the next-phase clinical trial. The ultimate goal of translational research is to move observations forward into clinical application. The intent of the TTSA is to leverage information from existing or completed clinical trials to address knowledge gaps in resulting outcomes. Studies may involve tissue or biopsy procurement or utilization of existing tissue sources. Of particular interest are studies investigating the differences in prognosis and treatment with respect to primary nodal status and/or the presence of metastatic disease; research on precursor lesions and the relationship to prevention and potential outcomes; investigations into tumor heterogeneity (e.g., genetic, epigenetic, immunological) and its association to the tumor microenvironment; and, studies on patient-reported outcomes and quality of life associated with treatment. The TTSA supports preclinical studies in animal models and human subjects and human anatomical substances. Accordingly, development or use of relevant preclinical models may be included. The TTSA is not intended to support high throughput screenings, sequencing, etc. Funding for the clinical trial is not allowed.

The TTSA requires that multiple investigators jointly design a single project, with comparable levels of intellectual input from each Principal Investigator (PI). However, each partner will be recognized as a PI, submit a separate application (even if the partners are at the same organization), and receive an individual award. The research project must be supported by the unique expertise, experience, and abilities of each PI; and it must clearly define the translational components that will facilitate and accelerate progress in a way that could not be accomplished through independent efforts. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PIs will be identified as Partnering PIs. Initiating and Partnering PIs each have different submission requirements, as described in
Section II; however, all PIs should contribute significantly to the development of the proposed research project. If recommended for funding, each PI will receive his or her own award.

Multidisciplinary projects are encouraged, and at least two organizations must be included in the application. Applications should include clearly stated plans for interactions among all PIs and organizations involved. The plans must include communication, coordination of research progress and results, and data transfer. Additionally, applications must provide an intellectual property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.


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pdf Translational Team Science Award