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Biology of the Temporomandibular Join in Health and Disease (R21) (R01)


Tuesday, June 16, 2015


The purpose of this FOA is to encourage research that will advance understanding of temporomandibular joint (TMJ) function in health and disease. Contemporary, multidisciplinary research focused on the biology of TMJ tissues, interactions of these tissues, innervation of the musculoskeletal component and vascularization of the joint, and normal developmental processes and disease progression are key research areas for expansion. This FOA is intended to complement previous research efforts on temporomandibular joint disorder (TMD) while focusing on the biology of joint function and tissues that make up the TMJ. In particular, this two-year R21 exploratory/developmental grant program would ideally support development of new model systems, agents, tools, methodologies, or technologies, as well as novel ideas that have the potential for significant impact in this field of research. A better understanding of total joint structure and mechanics including macroscopic and molecular interactions of the skeletal, muscular, nervous, immune, and circulatory systems is needed. In addition, the development of new in vivo and in vitro models to promote multiple facets of research including through the use of advanced tools and technologies to identify morphoregulatory factors is needed. An expected outcome of this FOA is new knowledge that will provide a basis for developing novel approaches to prevent, diagnose, assess risk, and treat TMD.   

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