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Nuclear Organization and Function Interdisciplinary Consortium (NOFIC)(U54)


Monday, February 23, 2015


This FOA seeks to establish technology-development and data-production centers whose mission will be to develop, benchmark, standardize, and validate the next generation of high-throughput technologies that can produce three dimensional physical and functional maps of mammalian genomes, develop predictive models of mammalian genome structure-function relationships, and test the relevance of new nuclear organizational principles within the context of specific biological paradigms and systems.  

The overarching goals of the 4DN Program are to understand the principles that guide the spatial and temporal organization of the nucleus, the role of this organization in orchestrating the transcriptional complexity in individual cells and tissues, and the way in which changes in nuclear organization affect development and disease processes. The Program consists of 6 initiatives, of which this FOA is one. Specifically, the initiatives are:

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